Screening Snake Venoms for Toxicity to Tetrahymena Pyriformis Revealed Anti-Protozoan Activity of Cobra Cytotoxins
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چکیده
منابع مشابه
Automated image analysis to improve bead ingestion toxicity test counts in the protozoan Tetrahymena pyriformis.
AIMS To improve bead ingestion counts in Tetrahymena pyriformis by automated image analysis as an alternative to direct-counts. METHODS AND RESULTS Fluorescent latex beads were added to T. pyriformis cultures for ingestion tests. The number of beads ingested by 25 cells was counted directly by epifluorescence microscopy and compared with similar data from image analysis. anova indicated that ...
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Cardiotoxins (cytotoxins, CT) are β-structured proteins isolated from the venom of cobra. They consist of 59-61 amino acid residues, whose antiparallel chains form three 'fingers'. In contrast to neurotoxins with an overall similar fold, CTs are amphiphilic. The amphiphilicity is caused by positively charged lysine and arginine residues flanking the tips of the loops that consist primarily of h...
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An alternative in vitro approach to drug screening has been the use of human cell cultures for antiviral agents and microbial cell cultures for the assessment of the carcinogenic potential of selected compounds. A number of protozoan species have been also used as drug screens for anti-protozoal agents. The ciliated protozoan Tetrahymena pyriformis species has been widely utilised as a dru...
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Gravitactic bioconvective patterns created by Tetrahymena pyriformis in a Hele-Shaw apparatus were realized and compared with theoretical results. There were found to be two thresholds for bio-convection development: the first indicates the transition from the diffusion to the steady convection state; the second corresponds to the transition from the steady to the unsteady convection state. The...
متن کاملQuantitative Structure Activity Relationship using MLR Method for Nitrobenzenes Toxicity to tetrahymena pyriformis
The toxicity data of 42 nitroaromatic compounds related to 50% growth inhibitory concentration (log IGC50) were used to develop Quantitative structure toxicity relationship to tetrahymena pyriformis.The multiple linear regression method was applied to select the descriptors.The six parametric model were found to be the best which gives a variance of more than 92% (R2=0.9248). Our results have s...
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ژورنال
عنوان ژورنال: Toxins
سال: 2020
ISSN: 2072-6651
DOI: 10.3390/toxins12050325